2021

Duliëtte Boon

ISTH. Oral Communication: Non-invasive Early Exclusion of Chronic Thromboembolic Pulmonary Hypertension (CTEPH) after Pulmonary Embolism

Jacob G. Ludington

ASH. Plenary Session: SARS-CoV-2 Ion Channel ORF3a Enables TMEM16F-Dependent Phosphatidylserine Externalization to Augment Procoagulant Activity of the Tenase and Prothrombinase Complexes

Sol Schulman

ASH. Plenary Session: SARS-CoV-2 Ion Channel ORF3a Enables TMEM16F-Dependent Phosphatidylserine Externalization to Augment Procoagulant Activity of the Tenase and Prothrombinase Complexes

Sukhraj Pal Singh Dhami

ISTH. Oral Presentation: Delineating the Role of Low Molecular Weight Heparin in Breast Cancer Metastasis

Hunter B. Moore

ISTH. Presentation on dynamic changes in fibrinolysis during liver transplantation

Sajida Kazi

ISTH. Abstract on the ISTH Registry on Pregnancy and COVID-19 Associated Coagulopathy

2020

Hanny Al-Samkari

ISTH2020. Presentation: Thrombosis, bleeding, and the effect of anticoagulation on survival in critically ill patients with COVID-19 in the United States.

Matthias Engelen

ISTH2020. Presentation: Incidence of venous thromboembolism in patients discharged after COVID-19 hospitalization.

Imre Varju

ISTH2020. Presentation: Fibrinogen is citrullinated in venous thrombi and forms fragile clots with increased resistance to lysis.

Ellen Driever

International Liver Congress (ILC 2020). Presentation: The VWF/ADAMTS13 imbalance, but not global coagulation or fibrinolysis, is associated with outcome and bleeding in patients with acute liver failure.

Christine Lee

ASH2020. Presentation: Soluble platelet agonists expand the procoagulant surface in heparin-induced thrombocytopenia.

Maria Selvadurai

ASH2020. Presentation: Soluble platelet agonists expand the procoagulant surface in heparin-induced thrombocytopenia.

2019

ELISA DANESE

ISTH2019. Presentation: epigenetics in hemostasis.

SORACHA WARD

2018 American Society of Haematology Conference (San Francisco). Presentation: defining the molecular mechanisms through which the macrophage galactose lectin (MGL) receptor regulates von Willebrand factor clearance.

JONATHAN DOUXFILS

ISTH2019. Presentation: a new algorithm based on thrombin generation to assess hormone-related prothrombotic changes.

11th ECAT meeting—Leiden (Netherlands; 2018) presentation: interference of DOACs on coagulation tests.

ERIK KLOK

ISTH2019. Presentation: evaluation of the predictive value of the bleeding prediction score “VTE-BLEED” for recurrent venous thromboembolism.

MICHELLE LAVIN

ISTH2019. Presentation: VWD and pregnancy—results of an International Survey.

DEEKSHA KHIALANI

ISTH2019. Presentation: thrombosis risk after switching oral contraceptive type.

2018

MARK SCHREUDER

ASH 2017 USA Presentation: Phe174-Mutated Human Factor X As Bypassing Agent to the Direct FXa Inhibitors

JAMES McFADYEN

9th Haemostasis Update Meeting, 2018 Melbourne: Role of platelets in haemostasis and thrombosis

DAVID RABBOLINI

9th Haemostasis Update Meeting, 2018 Melbourne: Platelet function testing

JANKA ŽOLKOVÁ

XXVth Slovak-Czech conference on hemostasis and thrombosis, Martin, Slovakia, 2018: Genetic background of von Willebrand disease

TOMÁŠ BOLEK

XXVth Slovak-Czech conference on hemostasis and thrombosis, Martin, Slovakia, 2018: Proton pump inhibition affects the dabigatran on-treatment levels in patients with atrial fibrillation

FRASER MACRAE

2nd Joint Meeting of the International Society of Fibrinolysis and Proteolysis and the Plasminogen Activation Workshop, Edinburgh, UK, 2018: External blood clots are covered by a fibrin bio-film that protects against infection

2017

IVAR VAN ASTEN

ISLH 2016 presentation: Diagnostic value of a flow cytometry based platelet function test compared with light transmission aggregometry in patients with unknown bleeding disorders.

LAURA FRANCO

ISTH 2017 presentation: Mortality in Patients with Intracerebral Haemorrhage Associated with Vitamin K Antagonists, Direct Oral Anticoagulants, Antiplatelets or No Antithrombotic Therapy

ELODIE LARIDAN

ISTH 2017 presentation: Neutrophil Extracellular Traps In Thrombi from Patients with Acute Ischemic Stroke

LEONARDO PASALIC

ISTH 2017 presentation: Patients with Coronary Artery Disease Have a Pathological P2Y12 Platelet Response with Heightened Procoagulant Platelet Potential

YVONNE BRENNAN

ISTH 2017 presentation: Dental Extractions on NOACs without Stopping Therapy (DENTST) Study

GEORGIA MCCAUGHAN

ISTH 2017 presentation: Choice of Anticoagulation in the Obese

2016

SOUNDARYA SELVAM

ISTH SSC 2016 presentation: Blood outgrowth endothelial cells from type 3 von Willebrand disease patients display abnormal angiogenesis

VINCENT MUCZYNSKI

ISTH SSC 2016 presentation: A novel factor VIII–nanobody fusion protein displaying prolonged half-life and hemostatic efficacy in vivo

KAREN SCHREIBER

ISTH SSC 2016 presentation: HYPATIA—A prospective randomized controlled trial of HYdroxychloroquine versus placebo during Pregnancy in women with AnTIphospholipid Antibodies

ADI J. KLIL-DRORI

2016 ASH presentation: The Risk of Major Bleeding with Low-Molecular-Weight-Heparins for Venous Thromboembolism in Dialysis Patients: The Q-VTE Study

LINDSEY GEORGE

2016 ASH presentation: Adeno-Associated Virus Mediated Gene Transfer for Hemophilia B Achieves Sustained Mean Factor IX Activity Levels of >30% without Immunosuppression

JASMINE TAY

HAA 2016 presentation: Validation of plasma miR-494–3p and miR-365a-3p expression levels as indicators of thrombotic risk

2015

JURAJ SOKOL

DLTH 2015 presentation: Genetics of sticky platelet syndrome and fetal loss

LJUBICA JOVANOVIĆ

DLTH 2015 presentation: Practical aspects of monitoring of antiplatelet therapy

LUCIA STANCIAKOVA

DLTH 2015 presentation: Rotational thromboelastometry and monitoring of anticoagulation in pregnant women with increased risk of fetal loss

TINA BISS

ISTH 2015 presentation: Venous thromboembolism occurring during adolescence: is it preventable?

TOBIAS FUCHS

ISTH 2015 presentation: DNA in plasma indicates disease extent and predicts mortality in patients with venous thromboembolism

JONATHAN M. COUTINHO

ISTH 2015 presentation: Is anemia a risk factor for cerebral venous thrombosis?

2014

DR. ANDREAS TIEDE

ASH presentation: Prognostic Parameters For Remission Of and Survival In Acquired Hemophilia A: Results Of The GTH-AH 01/2010 Multicenter Study

DR. WENDY LIM

ASH presentation: Antiphospholipid Syndrome

DR. RITEN KUMAR

WFH presentation: Exercise increases FVIII, von Willebrand factor and platelet counts in boys with hemophilia A and B: preliminary findings of the SickKids hemophilia exercise study

DR. MARIA ELISA MANCUSO

WFH presentation: Thrombin generation assay in hemophilic patients with or without inhibitor undergoing orthopedic surgery

DR. SUSANA NOBRE FERNANDES

WFH presentation: Economic impact of individualized prophylaxis approach on a severe hemophilia young adult cohort

DR. COEN MAAS

ISLH presentation: Detection of Plasma Contact System Activation in Thrombotic

2012/2013

DR. VIVIAN XIAOYAN DU

ASH presentation entitled “Binding of erythrocyte ICAM-4 to the platelet activated integrin α_IIbβ₃ leads to a direct erythrocyte-platelet adhesion under venous flow shear rate”

DR. ANDREW YEE

ASH presentation entitled “Partial in vivo FVIII stabilization by VWF fragments”

DR. SARAH O’BRIEN

ASH presentations, one being related to use of bivalirudin in children with venous thromboembolism and the other assessing von Willebrand Disease in adolescents

DR. VERONICA FLOOD

ASH presentation on von Willebrand Disease testing

JULIE TANGE

Mayo Coagulation Quality presentation on issues related to verification and assignment of International Sensitivity Index (ISI) values for determination of International Normalized Ratio (INR) values across different laboratories in a large network

KENT CHAPMAN

Presentation at a large Australian regional meeting comprising a conjoint scientific meeting of the Haematology Society of Australia and New Zealand, Australian and New Zealand Society of Blood Transfusion,and Australasian Society of Thrombosis and Haemostasis

2011

DR. ROMARIC LACROIX

Aix-Marseille University, France. For presentations delivered at the XXIII ISTH Congress in Kyoto, Japan, 2011

DR. TIM GANDERTON

Presentation at HAA2011 on his recently awarded Ph.D. topic, namely the “Mechanism of Lateral Self-Association of Von Willebrand Factor,” the data from which he recently published in the journal Blood.

PH.D. CANDIDATE BRAD McEWEN

Presentation at HAA2011, on the topic of “Low Dose Omega-3 on Fibrin and Thrombin Generation in Healthy Volunteers and Patients with Cardiovascular Disease.”

DR. VIVIEN CHEN

Oral presentations at HAA2012, including a detailed presentation on insights into thrombus initiation gained through intravital imaging.

DR. NEIL GOLDENBERG

Spoke at ISTH, and currently holds several clinical and academic positions, although in essence is a pediatric hematologist interested in pediatric hypercoagulability. Dr. Goldenberg has most recently developed a new global hemostasis assay (the clot formation and lysis assay, CloFAL).

DR. JOSEPH E. ITALIANO

Presentations at ISTH, including a talk in the Platelet Symposium in which he described the outstanding results of his work on megakaryocyte and the formation of platelets, as well as the role of platelets in angiogenesis.

2010

Dr. Adam Cuker (University of Pennsylvania)

Presentation at the 2010 American Society of Hematology meeting on immune thrombocytopenia (ITP), as well as his work related to a novel expert-based clinical scoring model for heparin-induced thrombocytopenia (HIT).

Dr. Jayandharan Giridhara Rao (Christian Medical College, Vellore, Tamil Nadu)

Papers on quality assurance in genetic testing for disorders of hemostasis, and the role of new technologies in hemophilia diagnosis and therapy at the Hemophilia World Congress in Argentina in 2010.

Dr. Timea Szanto (Helsinki University Central Hospital)

Presentation on platelet function and von Willebrand disease (VWD) at the Nordic Coagulation Meeting in 2010.

Dr. Birgitta Salmela (Helsinki University Central Hospital)

Paper on laboratory monitoring of new anticoagulants presented at the Nordic Coagulation Meeting in 2010.

Dr. Pia Riittaa-Maria Siljander (University of Helsinki)

Presentation on platelet-derived micro-particles given at the Nordic Coagulation Meeting in 2010.

2009

Dr. Salley Pels

Dr. Salley Pels was nominated for her award as a result of an oral presentation she gave at the recent American Society for Hematology (ASH) 51st Annual Meeting held in December 2009, on the use of intravenous immune globulin in immune thrombocytopenia. Dr. Pels received her undergraduate degree in Chemistry at the Johns Hopkins University. She then went on to the University of Vermont College of Medicine for her Medical degree. Her training continued at Yale University and Yale-New Haven Children's Hospital, during a residency in General Pediatrics. Dr. Pels is currently nearing the end of a fellowship in Pediatric Hematology and Oncology at this facility. She has planned to complete an additional fellowship year in Clinical Hemostasis and Thrombosis, through a two-year award given by the National Hemophilia Foundation and Baxter.

Dr. Pels was granted several other awards in 2009, the Hemophilia and Thrombosis Research Society Young Investigators' Travel Award and the ASH Travel Award. Dr. Pels will prepare a paper on Immune Thrombocytopenia, the topic of her ASH presentation, for Seminars in Thrombosis and Hemostasis that is expected to appear in press sometime in 2011. We congratulate Dr. Pels on her award, look forward to her contribution to this journal and wish her the best of success for her future career.

Dr. Willem M. Lijfering

Dr. Willem M. Lijfering was also nominated for his award as a result of an oral presentation he gave at the same meeting, the recent American Society for Hematology (ASH) 51st Annual Meeting held in December 2009. Dr. Lijfering's topic was on the risk of venous thrombosis as related to an increase in body mass index and as mediated by factor VIII induced activated protein C resistance. Dr. Lijfering was born in 1978 and was trained in Europe. Dr. Lijfering was awarded his MD in May 2004, and his first clinical experience was obtained in Australia where he worked as a resident medical officer at the Mount Isa Base Hospital.

From 2005 till 2009, he worked as an internist in training in the UMCG, Groningen, the Netherlands. He started a PhD in 2005, which was awarded in 2008, and began his training as a Clinical Epidemiologist in 2009. Dr. Lijfering has had a very successful career to date, and from 2006 onwards, has presented or supervised more than 24 communications to international congresses of which 11 were oral communications. He has managed to publish 11 articles over the past year, all related to venous thrombosis, including several in high impact journals such as Blood and Circulation. Willem Lijfering has a particular and long-term interest in arterial and venous thrombosis, and has agreed to prepare a paper on the topic of his ASH presentation for Seminars in Thrombosis and Hemostasis that is also expected to appear in press sometime in 2011. We congratulate Dr. Lijfering on his award, look forward to his contribution to this journal and wish him the best of success for his future career.

Learn more about the Eberhard F Mammen awards by selecting the following links:

• Eberhard F. Mammen Awards: General Information
• Most Popular Article Award Winners
• Award Terms and Conditions
• Seminars in Thrombosis and Hemostasis Product Page

2022 AWARD WINNERS

General Category

Anders Abildgaard, Sofie A. Madsen, Anne-Mette Hvas

Dosage of Anticoagulants in Obesity: Recommendations Based on a Systematic Review

From Anne-Mette Hvas, speaking also on behalf of her co-authors: “We were surprised and greatly honored to receive one of the 2022 Eberhard F. Mammen ‘Most Popular’ awards for the ‘General Category.’ The idea of our article entitled ‘Dosage of anticoagulants in obesity: recommendations based on a systematic review’ originated from questions regarding anticoagulant treatment of obese patients that came with increasing frequency in our center of thrombosis and hemostasis. We are grateful to know that our article was widely read by medical doctors, presumably treating obese patients in daily clinical practice; a clinical challenge that has been increasing during the last decade world-wide. And we strongly hope that our article was helpful to guide anticoagulant management of these patients.”

Oliver Grottke, Shuba Mallaiah, Keyvan Karkouti, Fuat Saner, Thorsten Haas

Fibrinogen Supplementation and Its Indications

From Oliver Grottke, speaking also on behalf of his co-authors: “We are delighted to be bestowed a 2022 Eberhard F. Mammen ‘Most Popular’ article award for our article entitled ‘Fibrinogen Supplementation and Its Indications.’ This honor affirms our commitment to dissemination of new clinical developments and applications of point of care guided fibrinogen replacement strategies to restore hemostasis and minimize blood loss and transfusions. I would like to thank my wonderful co-authors for all their contributions to the field of perioperative blood management in various settings, including postpartum hemorrhage, cardiac surgery, trauma, liver disease, and pediatric patients. This wide input substantially improved the relevance of the paper to the journal's readership. Although we need further clinical studies to answer several important clinical questions, existing data do indicate that, in patients with ongoing bleeding related to acquired hypofibrinogenemia, fibrinogen concentrate has important advantages over frozen plasma and cryoprecipitate. Thank you again for the opportunity to share this paper with your readership and for the award. We are extremely honored.”

Open Access Category

Alessandro Di Minno, Pasquale Ambrosino, Ilenia Calcaterra, Matteo Nicola Dario Di Minno

COVID-19 and Venous Thromboembolism: A Meta-analysis of Literature Studies

From Matteo Di Minno and Pasquale Ambrosino, speaking on behalf of all coauthors, “We are greatly honored to have received one of the ‘2022 Eberhard F. Mammen Seminars in Thrombosis and Hemostasis Most Popular Awards.’ We are delighted and thrilled that our manuscript on a topic of great interest in this pandemic period has been widely read by the scientific community. A major concern in severe COVID-19 is represented by a concomitant pro-thrombotic state. Thus, the aim of our meta-analysis was to provide timely information on the cumulative prevalence of venous thromboembolism in this clinical setting. It was gratifying to observe that our findings, although published at an early stage of the pandemic, were later confirmed by subsequent studies. Therefore, we found that our work was truly necessary and that it has hopefully increased the focus on the need for adequate screening procedures and antithrombotic strategies in COVID-19 patients. We are extremely happy to have presented our findings in this prestigious journal.”

Afaf Allaoui, Akif A. Khawaja, Oussama Badad, Mariam Naciri, Marie Lordkipanidzé, Fadila Guessous, Younes Zaid

Platelet Function in Viral Immunity and SARS-CoV-2 Infection

From Dr. Younes Zaid, speaking on behalf of all authors (some of whom also appear in, “It is a true privilege and great honor to be granted one of two Eberhard F. Mammen Seminars in Thrombosis and Hemostasis 2022 Most Popular Article Awards for the ‘Open Access Category,’ for our article entitled ‘Platelet Function in Viral Immunity and SARS-CoV-2 Infection.’ We were pleasantly surprised and really thrilled to hear that our paper reached a large readership; and this comforts our goal of enlightening the scientific community about platelet contribution to antiviral immunity and response during SARS-CoV-2 infection. Most importantly, we would like to thank the editors of STH for giving us the opportunity to publish our work in this prestigious journal. The award will be spent wisely to further fund our research related to COVID-19.”

2021 AWARD WINNERS

General Category

Toshiaki Iba, Marcel Levi, Jerrold H. Levy

Sepsis-Induced Coagulopathy and Disseminated Intravascular Coagulation

From Toshiaki Iba, speaking on behalf of all authors, “we are greatly honored to have received one of the Eberhard F. Mammen STH 2021 “Most Popular” article awards. Upon receiving the award, we must confess that the concept of disseminated intravascular coagulation (DIC) has not yet been integrated between the scientists and countries per se. DIC has perhaps become diffuse intercerebral confusion or disseminated intercontinental chaos. My wonderful colleagues Profs. Jerrold H. Levy and Marcel Levi and I have been worked on unifying the concept of sepsis-associated DIC and released the diagnostic criteria for sepsis-induced coagulopathy (SIC) in 2017. Since then, we are continuously working on expanding the “two-step approach (SIC to DIC)” to manage DIC in sepsis. Our future target is establishing an effective strategy for DIC. We also wish to clarify the difference and similarities between SIC and COVID-19-associated coagulopathy. We are extremely happy that we could introduce this process in this prestigious journal.”

James Thomas, Vadim Kostousov, Jun Teruya

Bleeding and Thrombotic Complications in the Use of Extracorporeal Membrane Oxygenation

From Jun Teruya, speaking also on behalf of his coauthors: “we were surprised, thrilled, and grateful to hear that our paper had won one of the 2021 Eberhard F. Mammen “Most Popular” awards for the “General Category.” We are pleased to know that our article entitled “Bleeding and Thrombotic Complications in the Use of Extracorporeal Membrane Oxygenation (ECMO)” was widely read by people who presumably manage patients on ECMO on a daily basis. Even with the advancement of recent technology, we still struggle with bleeding and thrombosis during ECMO. We hope that our article was helpful to guide management of patients on ECMO. On a personal note, I was fortunate to attend Dr. Mammen's talk when he came to Tokyo, Japan, in the late 1980's. I was a resident at that time, but his talk convinced me to specialize in hemostasis as my career.”

Open Access Category

Robert C. Gosselin, Dorothy Adcock, Akbar Dorgalaleh, Emmanuel J. Favaloro, Giuseppe Lippi, João M. Pego, Irene Regan, Virginie Siguret

International Council for Standardization in Haematology Recommendations for Hemostasis Critical Values, Tests, and Reporting

From Robert C. Gosselin, “on behalf of my coauthors, it is truly an honor to be bestowed two Eberhard F. Mammen “Most Popular” article awards. Dr Mammen had a particular fondness for teaching, especially laboratory technologists, which has inspired so many including myself to reach out and share our experiences. It is my belief that a significant feature for these awards is the acknowledgement that our colleagues yearn for these manuscripts that provide technical guidance, and thus we are immensely grateful to STH for their willingness to provide such a platform for these articles related to laboratory practice. I would also like to thank Siemens Healthcare Diagnostics for providing Dr. Marlar and myself the inspiration to write the preanalytical variable manuscript, as well as the ICSH for providing support for the coagulation critical value manuscript.”

Robert C. Gosselin, Richard A. Marlar

Preanalytical Variables in Coagulation Testing: Setting the Stage for Accurate Results

Richard A. Marlar added, “I wish to thank the editors and staff of STH for awarding Bob Gosselin and myself the honor of an Eberhard F. Mammen “Most Popular” article award for our article on preanalytical variables. Dr. Mammen truly was gifted for teaching and mentoring. I knew him throughout my career from his classroom teaching while in graduate school at the start of my career to mentoring and helping me set my direction into coagulation laboratory science. Finally, he continued to advise and mentor throughout my career on many different topics. It is truly an honor for me to have worked and interacted with him and his family. Thanks must be also extended to Siemens Healthcare Diagnostics for providing the opportunity to write a review manuscript on preanalytical variables in coagulation. And for the willingness of the editors of this journal to review and then accept our manuscript. It is gratifying to know that our work was truly needed and hopefully has helped make coagulation laboratories better.”

2020 AWARD WINNERS

General Category

Kishore Kumar, Mark Cowley, Ryan Davis

Next-Generation Sequencing and Emerging Technologies

Dr. Davis, speaking also on behalf of his co-authors, Drs. Kumar and Cowley stated: “We were extremely surprised, yet elated, that our invited review article was awarded an Eberhard F. Mammen Most Popular Award. The article had only been published a relatively short time prior to the award and especially given it was in the nonopen access category, we were delighted to hear it has been so popular with the readership of Seminars in Thrombosis and Hemostasis. The rise of next generation sequencing has been revolutionary for diagnosis and treatment of genetic diseases and has heralded vastly powerful resources in a rapidly evolving area. As mentioned in the review, the generation of large amounts of sequencing data is now routine and the true challenge lies in the analysis of the data. There is a general necessity for multidisciplinary teams to forge ahead and discover the unknown genetic causes of disease. This is perfectly highlighted by our multidisciplinary author team, together representing clinical, informatic, and basic disciplines. We are dedicated to understanding genetic disorders through the application of new genetic technologies. This article was written in the hope that it would make an introduction to next generation sequencing accessible to clinicians and basic scientists who were new to the area and provide a useful reference for the past, present, and future of next generation sequencing. With the open-access status granted by the Eberhard F. Mammen Award, we hope the popularity of this article continues well into the future. We are extremely grateful to the guest editors of our issue, Drs. David Rabollini and Maha Othman, for their support in shaping this article. We also thank the editors of Seminars in Thrombosis and Hemostasis for facilitating these awards to identify such popular articles.”

Vincenzo Russo, Emilio Attena, Carmine Mazzone, Francesca Esposito, Valentina Parisi, Ciro Bancone, Anna Rago, Gerardo Nigro, Raffaele Sangiuolo, Antonio D' Onofrio 

Nonvitamin K Antagonist Oral Anticoagulants Use in Patients with Atrial Fibrillation and Bioprosthetic Heart Valves/Prior Surgical Valve Repair: A Multicenter Clinical Practice Experience

Dr. Vincenzo Russo, on behalf of all authors stated: “We are truly honored to receive the Eberhard F. Mammen Seminars in Thrombosis & Haemostasis 2020 Most Popular Article Awards for our article describing the results of a multicenter clinical practice experience regarding the use of nonvitamin K antagonist oral anticoagulants (NOACs) in patients with atrial fibrillation and bioprosthetic heart valves or prior surgical valve repair. The Oral Anticoagulation Research Group, which I coordinate, involves some young researchers, from academic and nonacademic Italian institutions, focused on the evaluation of real-world NOACs clinical performance among “special populations,” not or less represented in randomized clinical trials. Today, it is no longer simple to perform independent real-world research activities; however, we think this is the only way to produce high quality scientific evidence that is not influenced from industry sponsorship. We gratefully thank the Editor-in-Chief of this journal and other involved editors/reviewers for enabling the publication of this original paper, describing the latest results of our research, and we are glad that all of the STH community have selected the paper for their scientific reading. The present award motivates us to progress forward, both morally and practically.”

Open Access Category

Giuseppe Lippi, Emmanuel J. Favaloro, Fabian Sanchis-Gomar

Sudden Cardiac and Noncardiac Death in Sports: Epidemiology, Causes, Pathogenesis, and Prevention

Giuseppe Lippi, also responded on behalf of his co-authors: “It is our pleasure and privilege to be bestowed the honor of one of two Eberhard Mammen Seminars in Thrombosis & Haemostasis 2020 Most Popular Article Awards for the “Open Access Category,” for our article entitled “Sudden Cardiac and Noncardiac Death in Sports: Epidemiology, Causes, Pathogenesis, and Prevention.” This honor affirms our desired goal of enlightening our clinical colleagues on the relevant issue of sudden death in sports, an issue that has become as actual as ever after the passing of a large number of sportsmen and sportswomen over the past 2 decades. I would also like to express my gratitude toward my long-standing research collaborators, and dear friends, Emmanuel J. Favaloro and Fabian Sanchis-Gomar, and to the Guest Editors of the issue of Seminars in Thrombosis & Hemostasis in which the article appears, for identifying the need for such an article as dedicated to this clinically substantial issue. We further hope that its contents would help to prevent—or at least mitigate—the number of recreational or professional athletes dying in the playgrounds in the very future. The award will be spent wisely to foster our laboratory research endeavors in the field of sport (laboratory) medicine, especially for funding our Run for Science (R4S) research project (http://www.r4s.it/en/home-en/), held under the auspices of the University of Verona, with the joint collaboration of many other worldwide Universities and Scientific Research Centres. R4S represents now the largest and most important scientific event concerning the world of endurance running, aimed at carrying out multidisciplinary analyses, reporting data, and obtaining scientific interpretations and discoveries in the fields of sport physiology and physiopathology.”

Karen Schreiber, Karen Breen, Hannah Cohen, Soren Jacobsen, Saskia Middeldorp, Sue Pavord, Lesley Regan, Dario Roccatello, Susan E. Robinson, Savino Sciascia, Paul T. Seed, Linda Watkins, Beverley J. Hunt

HYdroxychloroquine to Improve Pregnancy Outcome in Women with AnTIphospholipid Antibodies (HYPATIA) Protocol: A Multinational Randomized Controlled Trial of Hydroxychloroquine versus Placebo in Addition to Standard Treatment in Pregnant Women with Antiphospholipid Syndrome or Antibodies

Dr. Beverly Hunt, speaking on behalf of all authors, including Dr. Karen Schreiber stated “We feel humbled and extremely grateful that our study protocol for HYPATIA has won one of the Most Popular Article Awards for the “Open Access” Category 2019. HYPATIA is a European multicentre randomized controlled trial on hydroxychloroquine (HCQ) in addition to standard of care treatment in pregnant women with antiphospholipid antibodies (aPL). The study will answer the question if the addition of HCQ is beneficial in improving aPL-related pregnancy outcomes. We have faced extreme political and bureaucratic challenges in the set-up of the study and are heartened by this award. For it is proof that there is interest in the international scientific community on this topic and that the study is necessary to improve the current standard of care in women with aPL contemplating pregnancy. We would like to thank all our co-authors who have given valuable input to the study design, and for their persistence and efforts in supporting HYPATIA. We are most grateful for STH to have given us the opportunity to publish this concept paper.” 

2019 AWARD WINNERS

General Category

Adi J. Klil-Drori, Vicky Tagalakis

Direct Oral Anticoagulants in End-Stage Renal Disease 

From Dr Adi Klil-Drori (Figure 7), who prepared his Most Popular Award winning contribution in collaboration with his colleague Dr Vicky Tagalakis (Figure 8), and most interestingly, this contribution was originally prepared as part of a previous (2016) Young Investigator Award15: “I am remarkably indebted to Seminars in Thrombosis and Hemostasis for having had the opportunity to write our review Direct Oral Anticoagulants in End-Stage Renal Disease as part of a 2016 Young Investigator Award. It is particularly humbling to learn that the topic chosen for this review of primarily local interest has attracted enough attention in the field to be recognized with a Most Popular Article Award. The editors at Seminars should be commended for the open dialogue that allowed the choice of this topic for the review and the constructive expression of ideas throughout its writing and critique. I would also like to take the time and thank my mentor and co-author Dr. Vicky Tagalakis for her support and guidance through the years of our collaboration, to which this shared award is a silver lining. Finally, a shout-out to all the CanVECTOR folks, the Canadian VTE network that supported me by a fellowship grant.”

Steve Kitchen, Stefan Tiefenbacher, Robert Gosselin

Factor Activity Assays for Monitoring Extended Half-Life FVIII and Factor IX Replacement Therapies 

From Bob Gosselin (Figure 9), responding also on behalf of his co-authors Dr Stefan Tiefenbacher (Figure 10) and Dr Steve Kitchen (Figure 11): "It is humbling to be bestowed the honor of an Eberhard Mammen Most Popular Article Award for our article entitled, “Factor Activity Assays for Monitoring Extended Half-Life FVIII and Factor IX Replacement Therapies.”  On a personal note, I remember Dr Mammen fondly, he was such a gregarious man with a passion to teach, especially laboratory technologists, which thus adds weighted value in receiving this award.  I thoroughly enjoyed the time we shared together and our collaboration on the PFA-100 project, which was eventually also published in this journal. My co-authors, Stefan Tiefenbacher and Steve Kitchen, should be acknowledged as providing the yeoman’s work on the latest award winning paper.  This honor affirms our desired goal of enlightening our clinical and laboratory colleagues about the rapidly changing field of hemophilia replacement therapy.  These new replacement therapies require more diligence on the part of the laboratory and technologist to provide accurate assessment of these extended half-life factor replacement drugs.  In addition, we would like to thank the editors of Seminars in Thrombosis and Hemostasis for identifying the need for an edition of the journal dedicated to laboratory testing in the arena of anticoagulation and replacement therapy. Lastly, I would like to thank Dr Dorothy Adcock, who shared the guest editor responsibilities with me on this issue of STH devoted to laboratory medicine."

Open Access Category

Douglas B. Kell, Etheresia Pretorius

To What Extent Are the Terminal Stages of Sepsis, Septic Shock, Systemic Inflammatory Response Syndrome, and Multiple Organ Dysfunction Syndrome Actually Driven by a Prion/Amyloid Form of Fibrin? 

From Dr. Douglas Kell (Figure 2): “Science advances in many ways; occasionally this arises from the synthesis of disparate ideas that are not necessarily seen as the mainstream but that come from mainstream experiments. Typically, these originate from ‘outsiders’ who happen to enter a field anew. Our paper falls into this category. My scientific collaboration with the brilliant and far-sighted Resia Pretorius started via the internet and has since been extended via an inter-laboratory travel scheme funded by the UK BBSRC (Biotechnology and Biological Sciences Research Council). It led to this award-winning paper, and illustrates precisely the power and importance of multidisciplinary collaborations.  What is especially gratifying is that the STH community has taken our ideas seriously enough to have studied our Open Access article in detail, and will – in the normal way of science – now dream up good experiments that will develop or constrain our proposals, especially those relating to our own novel findings of amyloidogenic blood clotting. We are most grateful to STH and to its thoughtful Editor-in-Chief in assisting this paper through the review and editorial process.”

From Dr. Resia Pretorius (Figure 3): “This was truly the best news yet for 2019! I am truly humbled, together with my long-standing research collaborator, and dear friend, Douglas Kell, to receive this award.  I am most grateful to Seminars in Thrombosis and Hemostasis, and in particular the Editor-in-Chief, for his accommodating handling of the paper; it made the author experience really pleasant. Thank you to STH for allowing us to publish our new concepts and line of thought about the role of bacterial components in disease and inflammation.   The award will be spent wisely to further fund our laboratory research endeavours.” 

Cecilia Beatrice Chighizola, Maria Gabriella Raimondo, Pier Luigi Meroni

Management of Thrombotic Antiphospholipid Syndrome 

From Dr Pier Luigi Meroni (Figure 4), speaking also on behalf of his coauthors Drs Cecilia Chighizola (Figure 5) and Gabriella Raimondo (Figure 6): “I am honored to receive together with Drs Cecilia Chighizola and Gabriella Raimondo an Eberhard F. Mammen Most Popular Article Award for 2019, for an article we published last year. In spite of the fact that antiphospholipid syndrome (APS) has been a formal independent clinical entity for more than 20 years, the knowledge on its pathogenesis has increased enormously, emphasizing the close connection between the immune system and the coagulation cascade. At the same time, we have changed and are still changing our management of APS patients; so, any updating on APS treatment is welcome. Cecilia, Gabriella and I tried to report such a feeling in our review article and we are truly glad that the paper attracted a lot of attention within the scientific community. In this regard, we really appreciate that our article will now be given a ‘free access’ status, which will foster its further distribution. The editors of Seminars in Thrombosis and Hemostasis have to be complimented on their capacity to recognize this need is in line with the usual policy of the Journal. I would like also to thank the Guest Editor of the issue in which the paper was published for the invitation to contribute our review article, and the publisher for providing the award.”  

2018 AWARD WINNERS

General Category

Thomas Gremmel, Andrew L. Frelinger III, Alan D. Michelson

Platelet Physiology 

From Dr. Thomas Gremmel: “I am grateful and truly honored to receive an Eberhard F. Mammen Most Popular Article Award in 2018 as it reflects the great interest in our work. It is amazing that our review on Platelet Physiology has already attracted a lot of attention within the scientific community, and was read and cited by many distinguished colleagues. I would like to thank my coauthors Alan D. Michelson and Andrew L. Frelinger for their support in preparing the article, Anne-Mette Hvas for her invitation to contribute a review article, and the publisher for providing the award. The editors of Seminars in Thrombosis and Hemostasis have to be complimented on their continued selection of very relevant topics for respective issues of the Journal. As a source of excellent review articles in thrombosis and hemostasis research, this journal plays a pivotal role in the dissemination of knowledge in the field. In this regard, I am particularly pleased that our article will now be given a ‘free access’ status, which will foster its further distribution.”

Susan Mallett

Clinical Utility of Viscoelastic Tests of Coagulation (TEG/ROTEM) in Patients with Liver Disease and during Liver Transplantation 

From Dr. Susan Mallett: “I was both delighted and surprised to receive the news that my review article had won a 2018 Eberhard Mammen award for the ‘general’ category. It is indeed a great honor, and highlights the degree of interest this article has attracted within the scientific community. It is especially valuable to me personally; as for so many years, outside of the field of perioperative medicine in which I practice; there has only been limited interest in the enormous potential of viscoelastic tests to provide clinically relevant and individualized information about the hemostatic status. Over the last decade, there has been a paradigm shift in the way coagulation in liver disease is understood, with much new and exciting work demonstrating that hemostasis is finely, albeit precariously, ‘re-balanced’ in stable patients with liver disease due to the multiple and complex changes that occur in the hemostatic system. The many limitations and inadequacies of conventional coagulation tests in terms of assessing bleeding and thrombotic risk in patients with liver disease are now recognized. Future research using global viscoelastic tests will undoubtedly help elucidate some of these risks, and also give more relevant information that has the potential to eliminate many precautionary component transfusions that are completely unnecessary. As a consequence, clinical practice may be significantly altered for the better. I would very much like to thank Professors Ton Lisman and Hau Kwaan, who guest edited the issue on Hemostatic Dysfunction in Liver Diseases, for having given me the opportunity to write this review article for STH.”

Open-Access Category

Adam Cuker, Eline T. Luning Prak, Douglas B. Cines

Can Immune Thrombocytopenia Be Cured with Medical Therapy?

From Dr. Adam Cuker: “On behalf of my coauthors, I am truly humbled and delighted to receive not one but two Eberhard Mammen 2018 Most Popular Article Awards. As with novelists, poets, and playwrights, we in the biomedical community write in the hopes of reaching and illuminating our audience and perhaps of moving the needle in our chosen field, if ever-so-slightly, in the direction of progress. These awards are a vindication of our work. I am deeply grateful to Seminars in Thrombosis and Hemostasis and to its founding Editor-in-Chief, Eberhard Mammen, for providing a platform for me to reach my audience.”

Adam Cuker

Clinical and Laboratory Diagnosis of Heparin-Induced Thrombocytopenia: An Integrated Approach

From Dr. Adam Cuker: “On behalf of my coauthors, I am truly humbled and delighted to receive not one but two Eberhard Mammen 2018 Most Popular Article Awards. As with novelists, poets, and playwrights, we in the biomedical community write in the hopes of reaching and illuminating our audience and perhaps of moving the needle in our chosen field, if ever-so-slightly, in the direction of progress. These awards are a vindication of our work. I am deeply grateful to Seminars in Thrombosis and Hemostasis and to its founding Editor-in-Chief, Eberhard Mammen, for providing a platform for me to reach my audience.”

2017 AWARD WINNERS

General Category

Kochawan Boonyawat, Mark A. Crowther

Venous Thromboembolism Prophylaxis in Critically Ill Patients 

From Drs. Mark Crowther and Kochawan Boonyawat: “We would like to thank the publishers for the honor of receiving the ‘Eberhard F. Mammen’ Award. Receiving such an award is one of the rare ways that we, as authors, realize the impact that our work is having. Review articles are undervalued in the scientific community because they are perceived to be less rigorous than ‘original science.’ Such awards, however, remind us that for most clinicians it is summaries and overviews that guide their practice. Seminars in Thrombosis & Hemostasis has always been regarded as a leading journal for high quality reviews across the spectrum of thrombosis and hemostasis; thus, to receive this award is a rare honor given the outstanding authorship list that this journal is able to command. It is also a great pleasure to find a journal that has put in place such an award for authors fortunate to work in areas of high clinical and research interest—the journal is to be congratulated on making this effort which is almost, in my opinion, unique. We look forward to working with Seminars in Thrombosis & Hemostasis in the future and to provide further contributions to the literature in this area.”

Marcel Levi, Tom van der Poll

Coagulation in Patients with Severe Sepsis 

From Dr. Marcel Levi, also on behalf of his coauthor Dr. Tom van der Poll: “I am most honored that this article has attracted so much attention. It is, in particular, wonderful that an article building on the work of Eberhard F. Mammen, published in the journal for which he was the leading editor for many years, now awards a prize in his name. I am really very proud. It is always very good to learn that a review article is well received and read by many colleagues and I can only hope it has been helpful for practicing physicians and researchers in this field.”

Open-Access Category

Gary W. Moore

Recent Guidelines and Recommendations for Laboratory Detection of Lupus Anticoagulants

From Dr. Gary Moore: “I am truly honored to receive this award because it reflects a degree of interest from within our scientific community, which is both amazing and humbling. Writing the review was a labor of love, as lupus anticoagulant detection continues to fascinate, intrigue, and at times frustrate me. The relatively close publication of guidelines from three expert panels on how to detect these sometimes elusive antibodies was a fantastic opportunity to compare and contrast their recommendations, discuss some of the differences, and try to clarify some of the ambiguities. As a coauthor of two of the guidelines, I was in a good position to understand how different groups worked together to come to their sometimes similar/sometimes diverse conclusions, and hope I nonetheless managed to be informative and objective in my synopsis. One always hopes that a publication will touch many professional lives, and thus to win this award confirms this to be so.”

Theodore E. Warkentin

Heparin-Induced Thrombocytopenia in Critically Ill Patients

From Dr. Theodore (Ted) Warkentin: “I was delighted to receive the wonderful—and unexpected—news that this heparin-induced thrombocytopenia (HIT) paper was identified as one of the ‘most popular articles’. Indeed, I like to share this paper with our McMaster hematology residents, as its concluding 1-page Appendix summarizes a helpful diagnostic and treatment approach to HIT; and the paper also addresses some vexing diagnostic issues, such as how to distinguish DIC-associated ischemic limb injury from that caused by HIT. I also would like to thank Professor Marcel Levi (University of Amsterdam), the Guest Editor of the issue (‘Thrombosis and Hemostasis Issues in Critically Ill Patients’) in which the HIT paper appears, for inviting the paper, and for overseeing the entire volume.”

2016 AWARD WINNERS

General Category

Philippe de Moerloose, Alessandro Casini, Marguerite Neerman-Arbez

Congenital Fibrinogen Disorders: An Update

From Dr. Philippe de Moerloose: “I am very honored to receive one of the 2016 Most Popular Article Awards for a review on Congenital Fibrinogen Disorders, written with my co-authors and close colleagues Alessandro Casini and Marguerite Neerman-Arbez. In Geneva, we have been working for more than 15 years on the genetic basis and clinical consequences of fibrinogen deficiencies. The fundamental knowledge gained in this field during the past decade has been quite substantial and has translated into a better comprehension of our patient phenotypes with a more tailored approach to their treatment. We are very pleased to learn that a large number of STH readers appreciated our updated review.”

Sanjeev Sethi, Fernando C. Fervenza

Pathology of Renal Diseases Associated with Dysfunction of the Alternative Pathway of Complement: C3 Glomerulopathy and Atypical Hemolytic Uremic Syndrome (aHUS)

From Dr. Sanjeev Sethi: “It is indeed an honor to be selected for one of the 2016 Most Popular Article Awards. Understanding the pathology behind C3 glomerulopathy and atypical hemolytic uremic syndrome is the key to the correct diagnosis, evaluation, and management of these patients. Over the last few years great advances have been made in understanding the role of alternative pathway of complement in C3 glomerulopathy and atypical hemolytic uremic syndrome. With better elucidation of the pathophysiology, the next step is the development of new agents that can target the specific underlying abnormality or defect that cause C3 glomerulopathy and atypical hemolytic uremic syndrome. I am very glad that our review of the pathology of these disease entities was well received, and I would also like to sincerely thank my colleague, friend and coauthor, Dr. Fernando Fervenza, with whom I have had numerous great discussions and collaborations.”

Open-Access Category

Shannon M. Bates

D-Dimer Assays in Diagnosis and Management of Thrombotic and Bleeding Disorders

From Dr. Shannon Bates: “I was surprised and very pleased to hear that my article had been awarded one of 2016 Most Popular Article Awards. Although I enjoy the opportunity that writing a review article provides to thoughtfully examine and synthesize the available literature, I must admit that I often wonder whether the resulting manuscript is of benefit to readers or even noticed. I am delighted, therefore, to find out that readers have found my article useful. It is an honor to receive this award.”

Giuseppe Lippi, Emmanuel J. Favaloro, Tiziana Meschi, Camilla Mattiuzzi, Loris Borghi, Gianfranco Cervellin

E-Cigarettes and Cardiovascular Risk: Beyond Science and Mysticism

From Dr. Giuseppe Lippi: “I was really delighted to know that our article on ‘e-cigarettes and cardiovascular risk’ had won one of the Eberhard Mammen Seminars in Thrombosis & Hemostasis 2015 most popular article awards. The issues of the possible health hazard posed by E-cigarettes is as relevant now as ever, if one considers that approximately two thirds of national governments around the globe have established strict regulations for e-cigarettes as of 2015. Briefly, in 2014 the European Union established new regulations forbidding advertising, setting limits on maximum concentrations of nicotine, limiting volumes of liquid that can be sold, requiring child-proof and tamper-proof packaging and empowering regulators to take act should the regulations be violated. In April 2014 in Australia, a court decision has made it illegal to sell or supply electronic cigarettes in Western Australia, regardless of their appearance or nicotine content. In the US, with a lack of federal regulations, many states use local e-cigarette regulations, most commonly to prohibit sales to minors. It is also noteworthy that the US Food and Drug Administration (FDA) agency has recently established an on-line database (i.e., Adverse Event Reports for e-Cigarettes), aiming to collect voluntary reports of adverse events involving e-cigarettes from consumers, health professionals and members of the public. Health concerns were mostly related to the evidence of enhanced risk of cardiac arrhythmias, hypertension and cardiovascular events, which may be further magnified by other potential effects such as increased respiratory and flow respiratory resistance. We are therefore really pleased that this article has generated such huge interest around this very actual public health issue.”

2015 AWARD WINNERS

General Category

Victor Tapson

Thrombolytic Therapy for Acute Pulmonary Embolism

From Dr. Victor Tapson: “I was delighted to hear that my article ‘Thrombolytic therapy for acute pulmonary embolism’ had won an Eberhard Mammen Seminars in Thrombosis & Hemostasis 2015 most popular article award...Even 40 years after publication of Urokinase/Streptokinase Pulmonary Embolism (PE) Trials, the indications for systemic thrombolysis, particularly in submassive PE, remain cloudy. Although the largest study to date has indicated no clear mortality difference when thrombolytics are administered in submassive PE, a large meta-analysis subsequently suggested improved mortality in this group....Because of the acute nature of these patients, the dilemma of whether to proceed with thrombolysis remains of tremendous interest to clinicians. Dr. Eberhard Mammen went to medical school in Germany, intending to take over his father's family practice. Those of us in the field of venous thromboembolism are very fortunate that he ultimately became involved in research, in addition to medical education and clinical practice.”

James N. George, Roseleen Charania

Evaluation of Patients with Microangiopathic Hemolytic Anemia and Thrombocytopenia

From Dr. James N. George: “This project was part of Dr. Roseleen Charania's Hematology-Oncology fellowship effort. We have had a lot of experience with patients who were initially suspected to have thrombotic thrombocytopenic purpura (TTP) but subsequently were discovered to have another etiology for the microangiopathic hemolytic anemia and thrombocytopenia. There have been many different etiologies. Dr. Charania's goal was to describe how we evaluate these patients. She did a superb job organizing our experience and presenting the critical points for patient evaluations. This was a great clinical project for her. She and I both learned a lot.”

Open-Access Category

Elaine M. Hylek

Anticoagulation Therapy for Atrial Fibrillation

From Dr. Elaine M. Hylek: “When I learned that I had received this award, I could not believe it. It is a true honor, especially coming from this community. The world of thrombosis has grown increasingly complex from basic mechanisms and treatments to the varied clinical settings and high-risk patients. Understanding the risks and benefits and helping our patients and colleagues make the most informed decisions was the overarching aim of this article.”

Cristhiam Rojas-Hernandez, David Garcia

The Novel Oral Anticoagulants

Dr. David Garcia provided the following commentary: “I am honored to receive one of the Eberhard Mammen Seminars in Thrombosis & Hemostasis 2015 Most Popular Article Awards. In my position, I am often asked to write review papers and I do occasionally wonder how many people benefit from the effort it takes to complete such a manuscript. In this case, I had the help of a superb colleague, Dr. Cristhiam Rojas-Hernandez (now a member of the Section of Benign Hematology at MD Anderson Cancer Center). We were fortunate to be invited to write this paper at a moment when there was a great deal of recently published, clinically actionable information available about the direct oral anticoagulants (DOACs), and I am very pleased to know that many Seminars readers found our synthesis of the evidence to be useful.”

2014 AWARD WINNERS

General Category

Kent Chapman, Michael Seldon, Ross Richards

Thrombotic Microangiopathies, Thrombotic Thrombocytopenic Purpura, and ADAMTS-13

Kent Chapman in response to his win: “As a scientist who performs ADAMTS-13 [a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13] assays in the laboratory, I came to write this paper not only out of personal interest in the subject matter, but also as a part of the Master's degree I was enrolled in at the time. I also felt that the literature at the time regarding TTP [Thrombotic Thrombocytopenic Purpura] was lacking a comprehensive review of TMA [Thrombotic Microangiopathies], TTP, and ADAMTS-13 and it was my aim to try and collate all this information in one paper to help others with the understanding of a very complex and often misunderstood disease. I am delighted to receive this award and even more excited to realise that the paper has been as popular as it is.”

Gili Kenet, Sofia Aronis, Yackov Berkun, Mariana Bonduel, Anthony Chan, Neil A. Goldenberg, Susanne Holzhauer, Alfonso Iorio, Janna Journeycake, Ralf Junker, Christoph Male, Marilyn Manco-Johnson, Patti Massicotte, Rolf Mesters, Paul Monagle, Heleen van Ommen, Leslie Rafini, Paolo Simioni, Guy Young, Ulrike Nowak-Göttl

Impact of Persistent Antiphospholipid Antibodies on Risk of Incident Symptomatic Thromboembolism in Children: A Systematic Review and Meta-Analysis

Drs. Gili Kenet and Ulrike Nowak-Göttl commenting their win: “Because thromboses and stroke in pediatric patients are rare diseases, conducting scientific studies within a single hospital or even within a single country is difficult. Aiming to gather scientific data and create recommendations that can be applied to a broad spectrum of children over the world we gathered together a large group of collaborators. We have previously chaired the pediatric/perinatal hemostasis scientific standardisation committee (SCC) of the International Society on Thrombosis and Haemostasis (ISTH), promoting international research collaboration and cooperative multicenter studies.”

Open-Access Category

Birgitta Salmela, Lotta Joutsi-Korhonen, Elina Armstrong, Riitta Lassila

Active Online Assessment of Patients Using New Oral Anticoagulants: Bleeding Risk, Compliance, and Coagulation Analysis

From Birgitta Salmela and Riitta Lassila: “The 2014 Eberhard F. Mammen ‘Most Popular' articles award both surprised and delighted our team… Winning this award encourages us to continue to be active in improving patient care, collaborate with our colleagues and to follow the field of new and developing anticoagulants. We are honored to be acknowledged in this way and look forward to reading the excellent articles appearing in Seminars in Thrombosis & Hemostasis in the future.”

2013 AWARD WINNERS

Cristiano Fava, Martina Montagnana, Emmanuel J. Favaloro, Gian Cesare Guidi, Giuseppe Lippi

Obstructive Sleep Apnea Syndrome and Cardiovascular Diseases

Obstructive sleep apnea syndrome (OSAS) is a chronic disease characterized by recurrent episodes of partial or complete upper airway collapse and obstruction during sleep, associated with intermittent oxygen desaturation, sleep fragmentation, and symptoms of disruptive snoring and daytime sleepiness. In this award winning article Fava et al. discuss the different aspects of the relationship between OSAS and pathogenically different conditions such as systemic hypertension, coronary artery disease, stroke, metabolic abnormalities, arrhythmias, and heart failure, and the authors also discuss the kaleidoscope of phenomena implicated in the pathogenesis of this challenging disease.

Antonella Tufano, Anna Guida, Matteo Nicola Dario Di Minno, Domenico Prisco, Anna Maria Cerbone, Giovanni Di Minno

Prevention of Venous Thromboembolism in Medical Patients with Thrombocytopenia or with Platelet Dysfunction: A Review of the Literature

Current guidelines for venous thromboembolism (VTE) primary prophylaxis are based on randomized clinical trials that exclude subjects at a potentially high bleeding risk. Thus no specific recommendation/algorithm for pharmacological prophylaxis in patients with thrombocytopenia and/or platelet dysfunction is available. In this article Tufano et al. provide information on this issue to optimize patients’ VTE prophylaxis.

2012 Award Winners

Giuseppe Lippi, Massimo Franchini, Emmanuel J. Favaloro, Giovanni Targher
Moderate Red Wine Consumption and Cardiovascular Disease Risk: Beyond the “French Paradox”

This article was listed as the top downloaded article of this journal for some 15 months over the past 2-year period, evidencing its enduring popularity. Perhaps the upbeat message of “moderate red wine consumption” having a positive effect on “cardiovascular disease risk” provided some of the momentum to its popularity. Dr. Lippi is an Associate Editor of, and a frequent contributor to, Seminars in Thrombosis & Hemostasis.

2011 Award Winners

Magdalena Sobieraj-Teague, Martin O’Donnell and John Eikelboom
New Anticoagulants for Atrial Fibrillation

Dr Sobieraj-Teague wrote this top article with colleagues at McMaster University in Canada during a 2-year postgraduate fellowship. She has since returned to Australia where she is a staff hematologist at Flinders Medical Center in Adelaide.

2010 Award Winners

Given the closeness in results for the second and third ranked articles from 2008-2009, the Editorial Board decided on three winners for the Most Popular Article Award in 2010.

Job Harenberg and Martin Wehling
Current and future prospects for anticoagulant therapy: inhibitors of factor Xa and factor IIa

Job Harenberg and Martin Wehling have collaborated for more than two years in the field of clinical and pharmacological research into thromboembolic diseases, and are based at Faculty of Medicine Mannheim at the University of Heidelberg, Germany. Dr Harenberg, the corresponding author for the paper, is a long-time contributor to Seminars in Thrombosis and Hemostasis. An old friend of Eberhard Mammen, Dr Harenberg was delighted to hear of his award.

Martin Wehling (left) and Job Harenberg (right) at an angiology
symposium in Kitzbühel, Austria

Margaret Prechel and Jeanine M. Walenga
The laboratory diagnosis and clinical management of patients with heparin-induced thrombocytopenia: an update

Margaret Prechel and Jeanine Walenga are colleagues working in the Departments of Thoracic and Cardiovascular Surgery and Pathology at the Loyola Medical Center in Maywood, Illinois, USA. They are co-directors of a reference clinical laboratory focused on heparin-induced thrombocytopenia (HIT).

Dr Walenga was the corresponding author on the winning article and was very pleased to hear news of their award from Dr Emmanuel J. Favaloro, the Editor in Chief of Seminars in Thrombosis and Hemostasis.

Margaret Prechel (left) and Jeanine Walenga (right) at the
Loyola University Medical Center in Maywood, Illinois, USA

Jawed Fareed, Debra A. Hoppensteadt, Daniel Fareed,
Muzaffer Demir, Rakesh Wahi, Melaine Clarke, Cafer Adiguzel, Rodger Bick
Survival of heparins, oral anticoagulants, and aspirin after the year 2010

The final award in 2010 is for an article by Jawed Fareed and an international group of colleagues working on anticoagulants. Dr Fareed is a long-standing author of Seminars in Thrombosis and Hemostasis, having contributed 115 articles to the journal. He too was greatly honored to receive notification of the award.

Dr Fareed and Dr Hoppensteadt work together at the Loyola University Medical Center. Their main area of research is the development of newer tests for the diagnosis of thrombosis and the objective elevation of newer drugs to treat thrombosis and cardiovascular disease.

Jawed Fareed (left) and Debra Hoppensteadt (right) at the
Loyola University Medical Center in Maywood, Illinois, USA

2009 Award Winners

Bruno Girolami and Antonio Girolami
Heparin-Induced Thrombocytopenia: A Review

Antonio and Bruno Girolami are a father and son co-authorship team. Antonio first met Eberhard Mammen about 25 years ago at the Meeting of the American Society of Hematology, and met him several times thereafter at various international meetings. The invitation to write the article came from the Guest Editor for that issue of Seminars in Thrombosis and Hemostasis (Paolo Prandoni) in consultation with Eberhard.

Bruno Girolami (left) and Antonio Girolami (right) outside of
the Institute of Semeiotica Medica at Padua University.

Kerstin Jurk and Beate E. Kehrel
Platelets: Physiology and Biochemistry

The invitation for Beate Kehrel to write her article came personally from Eberhard while at an international meeting, and both Beate and her co-author (Kerstin Jurk) were very happy to hear the news that they had won this award. In Beate's own words "Both of us love platelets and feel that we need to make scientists and medical doctors more familiar with the cinderellas of the blood cells".

Dr Emmanuel J Favaloro, the Editor in Chief of Seminars in Thrombosis and Hemostasis, met up with both Beate Kehrel and Kerstin Jurk at the recent ISTH meeting in Boston, and they expressed a wish to contribute further articles for this journal in the near future.

Beate Kehrel, Emmanuel Favaloro and Kerstin Jurk (left to right)
at the 2009 ISTH meeting in Boston.

Learn more about the Eberhard F Mammen awards by selecting the following links:

• Eberhard F. Mammen Awards: General Information
• Young Investigator Award Winners
• Award Terms and Conditions
• Seminars in Thrombosis and Hemostasis Product Page

Most Popular Article Awards

• Awarded to the authors of the most popular articles published in Seminars in Thrombosis & Hemostasis in the preceding two years as captured in the preceding year.
• The awards are determined by the Editor-in-Chief on the basis of user statistics from Thieme e-Journals. The decision of the Editor-in-Chief is final.
• The corresponding author of the winning articles will receive a check for US $1,000 and a commemorative plaque.
• Winning articles will be given “free access” status.
• Winning articles are automatically excluded from winning a future award.

Young Investigator Awards

Best presentation or meeting abstract by a young investigator – as presented or delivered to an international or large regional meeting on a topic related to the fields of thrombosis and hemostasis, and whose subject matter is determined to be in the spirit of Dr Mammen.

Up to six cash prizes of US$1,000 in any year. There are some additional considerations and conditions for the award, and awardees are expected to prepare a review or other paper related to the topic of their presentation (or as otherwise agreed) for publication in Seminars in Thrombosis & Hemostasis.

In general, previous award winners are excluded from a second award to enable more individuals to be recognized. After nominations are received, the awardees are selected by a vote of the Senior Editors of STH.

Any potential conflicts of interest are managed by first identifying these, and then excluding those with potential conflicts from voting.

Learn more about the Eberhard F Mammen awards by selecting the following links:

• Most Popular Article Award Winners
• Young Investigator Award Winners
• Seminars in Thrombosis and Hemostasis Product Page
• Medicine Awards: General Information